LDN is much more complex that you seem to believe
serious studies for over 20 years have been completed
on it's effects which work on the body the following
ways: ( Not Just metenkephalin response)
Naltrexone was approved by the FDA in 1984 in a 50 mg.
dosage as treatment for alcoholism and drug addiction.
In 1984 around the time that the drug was approved,
there were some mice studies performed by Dr. Zagon of
Penn State University on the effects of Naltrexone on
Mice. The study found that Naltrexone had stimulatory
and inhibitory effects on neuroblastoma's in mice,
depending upon the dosage of the Naltrexone (see the
attached paper paper by Dr. Zagon). The low dose
Naltrexone had a completely opposite effect to the 50
mg dosage.
About that same time, Dr. Bernard Bihari, who was the
drug commissioner of New York, took these initial
mouse studies and started experimenting with drug
addicts using different doses to see what level of
Naltrexone in humans will give the optimum benefit. He
found that at 4.5 mg maximum dosage, the body's
endorphins are increased 200-300% which translated to
an improved immune system.
Low dose naltrexone (4.5 mg or lower) affects tumor
growth through a mix of three possible mechanisms:
1. By inducing increases of metenkephalin (an
endorphin produced in large amounts in the adrenal
medulla) and beta endorphin in the blood stream;
2. By inducing an increase in the number and
density of opiate receptors on the tumor cell
membranes, thereby making them more responsive to the
growth-inhibiting effects of the already-present
levels of endorphins, which induce apoptosis (cell
death) in the cancer cells; and
3. By increasing the natural killer (NK) cell
numbers and NK cell activity and lymphocyte activated
CD8 numbers, which are quite responsive to increased
levels of endorphins.1 (abstract)
http://www.lowdosenaltrexone.org/ldn_and_cancer.htm
http://www.ncbi.nlm.nih.gov/pubmed/6300232?dopt=Abstract
So although the Naltrexone is the same chemical (and
requires a doctor's prescription) it can be prescribed
off-label (at lower dosages) which is what Low Dose
Naltrexone (LDN) is.
It has been very successful in preventing further
progression of persons with many forms of cancer, and
if taken after operation and treatment of the primary
cancer (operation, radiotherarpy and chemotherapy)
will restore the immune system back to functioning
normally (which the chemo/radiation essentially
destroys) and help prevent recurrence or what happens
in most cases, metastases from the original site.
Ask any doctor/oncologist and they will tell you that
once the cancer metastisizes, there is NO conventional
chemo treatment which is successful. However LDN has
had some successes even for metastatic cancers, in
slowing down the growth and preventing further
metastases.
Dee
- goldenmike@sbcglobal.net wrote:
> Hello Tad,
> What data there are on LDN makes it look like it works, to some degree about, 60% of the time. That's great, especially if you're in the 60%.
> I don't think there is a way to know ahead of time
> whether that is true for any given individual. You can't even
> determine this through some expensive testing on endorphin rebound
> reactions. When metenkephalin is given directly, not through LDN
> rebound, it is not successful much more than 60% of the time. Which
> reminds me.....you can buy metenkephelin from a company in Israel and administer it directly, thus bypassing the whole LDN thing.
> Google it.
> Mike
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