No one on the list has addressed the lack of
data in support of Dr. Simoncini's claims. No
one wants to address the basic science as so well
presented by Dr. Simoncini's own Italian
colleagues (below). The abstracts that I have
posted are not intended as a refutation of
Simoncini. They do show that the relationship of
pH and cancer is quite complex.
It is unnecessary for clinicians to understand
the chemistry that would buttress their
claims. It is necessary for them to show their
raw data in an intelligible form -- if they want
the respect of the professional world. This is
all the more important when one's claims run
counter to conventional science and understanding.
I get a terrible feeling of deja vu when looking
at Simoncini's website. We have been here before
with other European MDs who had the absolute best
cure for cancer. Whatever happened to Gonsalvez
and his thioproline cure? to Danopoulos and his
urea cure? Bonous and his whey cure? to DiBello
and his somatostatin cure? to Olivisatos and his
niacin cure? to Hamer and his trauma resolution cure?
What do these physicians have in common with
Simoncini? With their confidence, enthusiasm,
and testimonials they attracted many followers
and defenders, but none of these physicians saw
fit to publish supporting data. Their therapies
would slowly lose their shine and their
sycophants and proteges would drift off to find
new heros. The hangers on would talk darkly of conspiracies.
Simoncini would likely find more professional
favor were he to answer the questions in the
comments below the abstract. List members might
ask themselves why this cure hasn't been heralded
before when alkalosis is such a common
electrolyte disturbance. One would think
that subsequent "spontaneous remissions" would
be de rigeur. Why not just alkalinize by hyperventilating?
Vincent
At 11:59 AM 3/30/2008, Vincent wrote:
>For credentialed professionals the usual and
>credible way to release bona fide information is
>through peer-reviewed articles. There is no
>conspiracy to suppress such information. An example is:
>------
>
><<http://www.sciencedirect.com/science/journal/0304419X>http://www.sciencedirect.com/science/journal/0304419X>
>Biochimica et Biophysica Acta (BBA) - Reviews on Cancer
>Volume 1756, Issue 1, 25 September 2005, Pages 1-24
>
>The role of pH dynamics and the Na+/H+ antiporter
>in the etiopathogenesis and treatment of cancer.
>Two faces of the same coinone single nature
>
>Salvador Harguindey, Gorka Orive, José Luis
>Pedraz, Angelo Paradiso, and Stephan J. Reshkin
>
>aCentro Médico "La Salud"- c) Independencia,
>13-01004 Vitoria, Spain, and Biotechnology
>Institute (BTI), c) San Antonio 15-5°, 01005 Vitoria, Spain
>bDepartment of Pharmacy and Pharmaceutical
>Technology, Faculty of Pharmacy, University of
>the Basque Country, c) Paseo de las Universidades, 7-01006 Vitoria, Spain
>cLaboratory of Clinical Experimental Oncology,
>Oncology Institute of Bari, 70126 Bari, Italy
>dDepartment of General and Environmental
>Physiology, University of Bari, 70126 Bari, Italy
>Received 3 March 2004; accepted 30 June 2005. Available online 19 July 2005.
>
>Abstract
>
>Looked at from the genetic point-of-view cancer
>represents a daunting and, frankly, confusing
>multiplicity of diseases (at least 100) that
>require an equally large variety of therapeutic
>strategies and substances designed to treat the
>particular tumor. However, when analyzed
>phenotypically cancer is a relatively uniform
>disease of very conserved 'hallmark' behaviors
>across the entire spectrum of tissue and genetic
>differences [D. Hanahan, R.A. Weinberg, Hallmarks
>of cancer, Cell 100 (2000) 57–70]. This suggests
>that cancers do, indeed, share common biochemical
>and physiological characteristics that are
>independent of the varied genetic backgrounds,
>and that there may be a common mechanism
>underlying both the neoplastic
>transformation/progression side and the
>antineoplastic/therapy side of oncology. The
>challenge of modern oncology is to integrate all
>the diverse experimental data to create a
>physiological/metabolic/energetic paradigm that
>can unite our thinking in order to understand how
>both neoplastic progression and therapies
>function. This reductionist view gives the hope
>that, as in chemistry and physics, it will
>possible to identify common underlying driving
>forces that define a tumor and will permit, for
>the first time, the actual calculated
>manipulation of their state. That is, a rational
>therapeutic design. In the present review, we
>present evidence, obtained from a great number of
>studies, for a fundamental, underlying mechanism
>involved in the initiation and evolution of the
>neoplastic process. There is an ever growing body
>of evidence that all the important neoplastic
>phenotypes are driven by an alkalization of the
>transformed cell, a process which seems specific
>for transformed cells since the same
>alkalinization has no effect in cells that have
>not been transformed. Seen in that light,
>different fields of cancer research, from
>etiopathogenesis, cancer cell metabolism and
>neovascularization, to multiple drug resistance
>(MDR), selective apoptosis, modern cancer
>chemotherapy and the spontaneous regression of
>cancer (SRC) all appear to have in common a
>pivotal characteristic, the aberrant regulation
>of hydrogen ion dynamics [S. Harguindey, J.L.
>Pedraz, R. García Cañero, J. Pérez de Diego, E.J.
>Cragoe Jr., Hydrogen ion-dependent oncogenesis
>and parallel new avenues to cancer prevention and
>treatment using a H+-mediated unifying approach:
>pH-related and pH-unrelated mechanisms, Crit.
>Rev. Oncog. 6 (1) (1995) 1–33]. Cancer cells have
>an acid–base disturbance that is completely
>different than observed in normal tissues and
>that increases in correspondence with increasing
>neoplastic state: an interstitial acid
>microenvironment linked to an intracellular alkalosis.
>------ Comment
>Dr. Simoncini chose not to go the route that
>would win the respect of colleagues. When there
>are problems getting important clinical research
>published, the researcher can put all the raw
>data on his/her website or in any number of web
>publications. Any clinician knows how to display
>a matrix of all patients, diagnoses, stage of
>disease, past and current therapies, and
>assessment of results -- complete remissions,
>partial remissions, stabilization of disease, and
>progression of disease. From this we can draw our own conclusions.
>
>Dr. Simoncini's claims seem to go hand in hand
>with his unconventional candida theory of cancer,
>but he provides very little scientific support
>for either. His reporting of wonderful cures
>might be one hundred percent accurate, but why
>did he choose to present his information in the
>same wearying way that is usually selected by scientistic hucksters.
>
>The history of sodium bicarbonate is almost
>identical to the history of hydrogen peroxide and
>other oxygen therapies for cancer. It goes back
>many decades and has many true
>believers. Certainly some people have
>benefited. In any responsible reporting we would
>be told when the treatment can be expected to
>fall on its face. How well does it work on the
>many difficult sarcomas? on low grade
>carcinomas? on the various leukemias and
>lymphomas? on patients with drug resistance? in
>the face of co-morbid conditions? what about
>bone mets? are there ANY cases where the sodium
>bicarbonate promoted cancer growth or cancer metastasis?
>
>The way this therapy is now being presented, all
>cancer patients can now say, "Whoopee! I'm as
>good as cured. I just have to make a pilgrimage
>to Dr. Simoncini -- or at least see a physician
>who has paid for Dr. Simoncini's seminar."
>
>Vincent
[Non-text portions of this message have been removed]
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