I actually agree with you on this. We've used lactoferrin and bovine
collostrum for some time now as an immune system bolster. The thing
that I am concerned about is that lactoferrin is in the family of
transferrin proteins (in fact it is sometimes referred to as
lactotransferrin). The commonality is that all these transferrins
bind to and transport iron. I'm not sure how this might relate to
carrying iron into cancer cells which do have lactoferrin receptors.
It may very well be that the protein binds the iron even within the
cell and makes it unavailable. In a broad based anticancer program
with other nutritional components in place, lactoferrin might be very
appropriate. We must always keep in mind the "two edged sword
concept". Something might be helpful in one context and harmful in
another.
It's obvious that in vitro testing of artemisinin almost
had to involve iron loading in order to demonstrate the effect within
the cells. In vivo the cells are basically already topped off with
iron.
I don't consider aretemisinin a stand alone cancer treatment due to
absorption problems, but I have seen it cause swelling and
inflammation in subcutaneous tumors in a very predictable fashion; a
big reaction within a few hours of the first dose in a cycle,
followed by 5 or 6 days of gradually diminishing post dose reactions.
With a few days rest the effect can be reproduced. This makes it a
good adjunct to other cytotoxic herbs.
The "Laura" thing was a typo. I actually dislike Dr. Laura. I
would never confuse you with her.
Mike
Friday, July 18, 2008, 9:08:16 PM, you wrote:
DLL> Hi Dr. Mike
DLL> First of all I am not the biology expert that you are but I want to throw
DLL> out a few things that I know from experience and what I have in my files.
DLL> :o)
DLL> I have not experienced what you indicate in your email with clients or even
DLL> personally. I took lactoferrin as part of my treatment for cancer and I
DLL> have been well for 8 years. I am not advocating it as a stand-alone, by any
DLL> means, but as part of an effective protocol it certainly has merit.
DLL> There have been studies showing its benefit toward microbes, infections and
DLL> even Candida and, of course, it greatly improves the immune system. I have
DLL> seen it help with anemia many times as long as therapeutic dosaging is used.
DLL> Lactoferrin is not known to drive iron to cancer cells, in fact studies
DLL> indicate that the opposite happen in that it takes iron and makes it less
DLL> available to the cancer cells but more useable to the body.
DLL> http://www.sultanofsteel.com/nutr/lactof1.html
DLL> Personally, I have not seen the results with artemisinin that a lot of
DLL> people are talking about. We used it as part of a protocol six or seven
DLL> years ago when I was interning and just didn't see better or worse results.
DLL> Also, from what I read of Dr's Lai and Singh's work the good results were
DLL> seen in a petri dish using transferrin and artemisinin on leukemia cells.
DLL> Which I understand is usually all we have to go on when it come to natural
DLL> medicine. But there are a lot of things that will kill cancer cells in a
DLL> petri dish but when it comes to the body it becomes a different story.
DLL> Portion of information on Dr. Lai's work (released in 2005):
DLL> "In the current study, the researchers _hypothesized_ that they could
DLL> improve the anti-cancer potency of artemisinin further by attaching or
DLL> "tagging" it to transferrin, a protein that picks up iron in the blood and
DLL> then is transported into cells, especially cancerous ones. Once in the cell,
DLL> transferrin releases the iron, leaving it free to interact with artemisinin
DLL> and cause the deadly reaction.
DLL> The investigators tested the "artemisinin-tagged transferrin" on _human
DLL> leukemia cells and on normal human immune cells_. As hoped for, the compound
DLL> destroyed the leukemia cells, but had little effect on the normal cells."
DLL> Difference between transferrin & lactoferrin (yes they are in the same
DLL> family but not exactly the same)
DLL> http://ift.confex.com/ift/2004/techprogram/paper_20994.htm
DLL> From another site:
DLL> The ability of lactoferrin to bind to a variety of normal and leukemic blood
DLL> cells has led to a suggestion that the lactoferrin released by neutrophilic
DLL> leukocytes plays a role in modulating the immune and inflammatory responses.
DLL> Lactoferrin promotes the
DLL> aggregation of neutrophils and their adhesion to epithelial cells, and may
DLL> be the agent that causes neutrophils to accumulate at inflammatory sites.
DLL> Lactoferrin in its iron- saturated form is a highly active inhibitor of
DLL> myelopoiesis, leading to the suggestion
DLL> that lactoferrin might be useful in the treatment of leukemia."
DLL> Theories don't always work in vivo the way they may work in vitro and I know
DLL> you know that better than any one. Possibly the Dr.'s theory of using
DLL> transferrin with artemisinin is of this nature. I have read some
DLL> testimonies of people using only lactoferrin for leukemia and becoming
DLL> cancer free.
DLL> I think it is wise for cancer patients to research and consider lactoferrin,
DLL> especially those who have done or are doing chemotherapy, those with Candida
DLL> (which are most) and those fighting anemia. And if one believes that cancer
DLL> is caused by parasites, yeast, etc. then certainly it would be an excellent
DLL> choice.
DLL> Be Well
DLL> Loretta (who wishes her name was Dr. Laura <grin>)
DLL>
DLL> -----Original Message-----
DLL> Hello Dr.Laura,
DLL> Unfortunately, lactoferrin will drive more iron into cancer
DLL> cells. This is what Dr.s Lai and Singh used to ramp up the iron
DLL> content of the cancer cells before hitting them with
DLL> artemissinin.
DLL> If a cancer patient uses lactoferrin to address an anemia, it
DLL> would be prudent to use artemisinin at the same time.
DLL> Mike
--
Best regards,
Mike mailto:goldenmike@sbcglobal.net
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