[cancercured] Worm Pills, an Effective Treatment for Malignant Melanoma and Other Cancers

THURSDAY, AUGUST 14, 2008

Mebendazole is a generic, inexpensive prescription medicine used to
treat worm infections. This drug is called a spindle poison because
it interrupts the formation of microtubules, cellular filaments that
separate newly made DNA. Chemo drugs such as Taxol and alkylating
agents are also spindle poisons, but they have toxicities that
mebendazole does not have.

http://en.wikipedia.org/wiki/Mebendazole
http://www.mayoclinic.com/health/drug-information/DR600879

In the last few years, a number of studies have found that
mebendazole is a powerful inducer of apoptosis in a wide variety of
cancer cells, both in culture dishes and mouse models.
In the following study, half maximal cytotoxic doses of mebendazole
in the range 0.1 to 0.8 microM (VERY low) killed a wide diversity of
cancer cells, including lung, breast, ovary, colon and
osteosarcomas. These studies were also conducted in mice.
Mebendazole also inhibited angiogenesis.

http://www.ncbi.nlm.nih.gov/entrez/queryd.fcgi?db=pubmed&cmd=Retrieve&dopt=Abstract&list_uids=12231542&itool=pubmed_docsum

Unlike microtubule disruptive drugs such as Taxol and alkylating
agents, mebendazole does not harm normal cells.
The following study was published this month. It shows that
mebendazole kills two different strains of chemotherapy resistant
melanoma cells. One strain contained a mutant p53 protein while the
other harbored a normal p53 tumor suppresor protein. Mebandazole
kills the cells equally. The half maximal cytotoxic dose was 0.32
microM.

http://www.ncbi.nlm.nih.gov/entrez/queryd.fcgi?
db=pubmed&cmd=Retrieve&dopt=Abstract&list_uids=18667591&itool=pubmed_docsum

Cimetidine, the generic version of the anti-ulcer drug Tagamet,
promotes the toxicity of mebendazole by inhibiting its degradation
in the liver.

http://www.ncbi.nlm.nih.gov/entrez/queryd.fcgi?db=pubmed&cmd=Retrieve&dopt=Abstract&list_uids=3663452&itool=pubmed_d
ocsum

The average blood concentration of mebendazole after a single
clinical dose is 1.67 microM. This value vastly exceeds the
concentration of mebendazole needed to kill a host of different
cancer cells.

Mebendazole is usually sold as a chewable tablet. When chewed and
allowed to remain in the mouth for a short period, the mebendazole
can enter the blood through the mucosal
membranes of the mouth. Of course, it can also enter the blood via
the GI tract. This drug is extremely non-toxic even in doses of 4.5
grams a day.

Microtubule inhibitors are THE target of interest for chemo drugs.
In this case, a simple anti-worm drug inhibits microtubule
functioning at low non-toxic concentrations. In a culture dish and
in mice, mebendazole induces apoptosis in a diversity of cancer
cells at extremely low concentrations.

Unfortunately, this drug will NEVER enter clinical trials as a
treatment for cancer. There is no money to be made.
Fortunately, physicians can prescribe this drug for the treatment of
cancer without a clinical trial. This blog and the referenced
articles contain all the scientific justification that they will
need.

Stay tuned...
Grouppe Kurosawa, Medicine in the Public Interest

http://www.grouppekurosawa.com

This essay is reposted from our subscription blog in the public
interest.

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