[cancercured] B-cell lymphomas -- Arsenic + ascorbate

Joe,

I have often successfully treated B-cell NHL with
potassium arsenite and ascorbic acid (or better
with dehydroascorbate). If the patient has
multiple drug resistance (which undermines this
therapy), don't try BSO as suggested below. You
can get excellent results using ethacrynic acid,
glutamine, and menadione. A source of natural
arsenic is the fronds of the Chinese brake fern.

Vincent
*************************************************************************************
Blood, Vol. 93 No. 1 (January 1), 1999: pp. 268-277

Malignant Cells Can Be Sensitized to Undergo
Growth Inhibition and Apoptosis by Arsenic
Trioxide Through Modulation of the Glutathione Redox System

Jie Dai, Rona S. Weinberg, Samuel Waxman, and Yongkui Jing

From the Rochelle Belfer Chemotherapy Foundation
Laboratory, the Division of Neoplastic Diseases,
the Division of Hematology, the Department of
Medicine, Mount Sinai Medical Center, New York, NY.

Arsenic trioxide (As2O3) induces clinical
remission in acute promyelocytic leukemia (APL)
with minimal toxicity and apoptosis in
APL-derived NB4 cells at low (1 to 2 µmol/L)
concentration. We examined the basis for NB4 cell
sensitivity to As2O3 to identify experimental
conditions that would render other malignant
cells responsive to low concentrations of As2O3.
The intracellular glutathione (GSH) content had a
decisive effect on As2O3-induced apoptosis.
Highly sensitive NB4 cells had the lowest GSH and
the sensitivity of other cell lines was inversely
proportional to their GSH content. The t(14;18)
B-cell lymphoma cell line had low GSH levels and
sensitivity to As2O3 at levels slightly higher
than in APL cells. Experimental upmodulation of
GSH content decreased the sensitivity to As2O3.
Ascorbic acid and buthionine sulfoxide (BSO)
decreased GSH to a greater extent, and rendered
malignant cells more sensitive to As2O3.
As2O3-induced apoptosis was not enhanced by
ascorbic acid in normal cells, suggesting that
the combination of ascorbic acid and As2O3 may be
selectively toxic to some malignant cells.
Ascorbic acid enhanced the antilymphoma effect of
As2O3 in vivo without additional toxicity. Thus,
As2O3 alone or administered with ascorbic acid
may provide a novel therapy for lymphoma.

At 08:25 PM 3/1/2008, you wrote:
>The Diagnosis is now: "This weeks diagnosis, Low Grade B Cell Lymphoma to
>be treated with Rituxan.
>
>This is the third different diagnosis.
>
>
>Anyone having dealt with this and treated with Rituxan? Keep in mind, his
>dad is 76 or so.
>
>
>Joe C.

[Non-text portions of this message have been removed]

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