>I had lot of confidence in high dose VitC atleast theoritically ...
><http://www.juiceguy.com/Vitamin-C-is-a-fake.shtml>http://www.juiceguy.com/Vitamin-C-is-a-fake.shtml
The citation above was written 24 years ago and published in a right
wing contrarian Lyndon LaRouche's political paper, EIR. Arthur
Robinson was at war with Linus Pauling. See:
http://www.sourcewatch.org/index.php?title=Oregon_Institute_of_Science_and_Medicine
You don't get good science when tremendous egos, big money, and
political extremism come into play.
I am quoting from this Juice Guy source:
"The Mayo Clinic goes out and does a study to prove Pauling wrong -
and that's easy..."
What kind of science is this? Not a study to find out the facts, but
adversarial science, using science as a stick to hit someone on the
head. It is a little galling to read, "and that's easy." If Mr.
Juice Guy perused any chemistry text written by Pauling he would
realize what formidable intellect has been lost to the world. I have
read Pauling and he is not without sin. He once wrote "regime" when
he clearly meant "regimen." Fie !!!
Karl posted a citation that poo-poo'd ascorbate:
Ann Oncol. 2008 Jul 25.
Phase I clinical trial of i.v. ascorbic acid in advanced malignancy.
<http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=Search&Term=%22Hoffer%20LJ%22%5BAuthor%5D&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DiscoveryPanel.Pubmed_RVAbstractPlus>Hoffer
LJ,
<http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=Search&Term=%22Levine%20M%22%5BAuthor%5D&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DiscoveryPanel.Pubmed_RVAbstractPlus>Levine
M,
<http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=Search&Term=%22Assouline%20S%22%5BAuthor%5D&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DiscoveryPanel.Pubmed_RVAbstractPlus>Assouline
S,
<http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=Search&Term=%22Melnychuk%20D%22%5BAuthor%5D&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DiscoveryPanel.Pubmed_RVAbstractPlus>Melnychuk
D,
<http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=Search&Term=%22Padayatty%20SJ%22%5BAuthor%5D&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DiscoveryPanel.Pubmed_RVAbstractPlus>Padayatty
SJ,
<http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=Search&Term=%22Rosadiuk%20K%22%5BAuthor%5D&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DiscoveryPanel.Pubmed_RVAbstractPlus>Rosadiuk
K,
<http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=Search&Term=%22Rousseau%20C%22%5BAuthor%5D&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DiscoveryPanel.Pubmed_RVAbstractPlus>Rousseau
C,
<http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=Search&Term=%22Robitaille%20L%22%5BAuthor%5D&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DiscoveryPanel.Pubmed_RVAbstractPlus>Robitaille
L,
<http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=Search&Term=%22Miller%20WH%20Jr%22%5BAuthor%5D&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DiscoveryPanel.Pubmed_RVAbstractPlus>Miller
WH Jr.
Montreal Centre for Experimental Therapeutics in Cancer, Lady Davis
Institute for Medical Research, McGill University and the Jewish
General Hospital, Montreal, Quebec, Canada.
BACKGROUND: Ascorbic acid is a widely used and controversial
alternative cancer treatment. In millimolar concentrations, it is
selectively cytotoxic to many cancer cell lines and has in vivo
anticancer activity when administered alone or together with other
agents. We carried out a dose-finding phase I and pharmacokinetic
study of i.v. ascorbic acid in patients with advanced malignancies.
PATIENTS AND METHODS: Patients with advanced cancer or hematologic
malignancy were assigned to sequential cohorts infused with 0.4, 0.6,
0.9 and 1.5 g ascorbic acid/kg body weight three times weekly.
RESULTS: Adverse events and toxicity were minimal at all dose levels.
No patient had an objective anticancer response. CONCLUSIONS:
High-dose i.v. ascorbic acid was well tolerated but failed to
demonstrate anticancer activity when administered to patients with
previously treated advanced malignancies. The promise of this
approach may lie in combination with cytotoxic or other redox-active molecules.
-----------------------------------------------
Another miserable study published in a journal that is not about to
publish anything that praises ascorbate. With this kind of approach
you can easily make any therapy look bad. What is the purpose of
this investigation? Getting published? More grant money?
If you want to know the truth you take a completely different
approach. You go to those who are getting good results with
ascorbate, you hang around and watch what they do, see how they
screen their patients, note what other drugs and supplements are used
(or avoided), and ask them their opinions of why others fail. How
many researchers add menadione, subtract B-6, monitor G6PD/hemolysis?
Fresh asparagus is very high in ascorbate: 2,500 calories can contain
as much as 12 grams. Seven years ago I got a call from an elderly
woman with non-small cell lung cancer. She had no money for the
usual meds. I told her to eat plenty of asparagus with every meal
even if it came from a can. What would she be afraid of -- getting
cancer 30 years from now? The woman is still alive with no evidence
of cancer.
Vincent
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