A Cure For Leukemia?
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My friend, Rich Folts, sent me this article on leukemia last week. I
think you'll find it interesting if this subject is part of your life:
"Monday, December 31, 2007
Acute Myeloid Leukemia, Chronic Myeloid Leukemia, and Acute
Lymphocytic Leukemia Can be CURED by a Combination of Natural Medicines
This essay is reposted from our subscription Natural Medicine blog in
the public interest.
When I was a graduate student at Berkeley in the 1980's, I attended an
International Hematology Conference in San Francisco. I overheard a
conversation between one of America's prominent hematologists and some
of his colleagues.
'What would you do if you were diagnosed with acute myeloid leukemia?'
they asked.
'I would commit suicide,' he quickly responded.
Acute and chronic myeloid leukemia (AML and CML) are largely incurable
diseases. The drug Gleevec has showed some promise in the treatment of
CML, but it does not CURE the disease. Eventually, people taking
Gleevec become resistant to the drug. When this occurs, they become
susceptible to a 'blast crisis' which invariably ends their life
within months of diagnosis.
One of my friends died a horrible death from AML. He bled to death in
front of his entire family.
In 2005 a paper was published showing that the plant hormone
parthenolide induced apoptosis in AML stem and progenitor cells. This
cell death was mediated by a reduction in NF-kappaB, and an increase
in p53 activity. In some medical circles, parthenolide is now
considered a stand alone CURE for CML.
Unfortunately, parthenolide is not soluble in water thereby severely
limiting its bioavailability in the body.
In December, 2007, an orally available form of parthenolide was
developed by the authors of the first study. In tissue culture and dog
studies, this orally available form of parthenolide killed AML stem
and progenitor cells and blast cells from both CML and acute
lymphocytic leukemia. Normal stem cells were not harmed.
Parthenolide is active at very low concentrations (5 microM). Although
this compound is not soluble in water, it can be introduced topically
into the body via a DMSO gel. We will discuss this protocol in future
essays.
Methyl jasmonate can induce the differentiation of AML and other
leukemic cells into normal cells. This has nothing to do with killing
stem or progenitor cells. This form of re-differentiation is well
established in the lab, but the toxicity of the chemicals prevents
their use clinically. MJ is active in the re-differentiation process
at VERY LOW concentrations, 0.4 mM.
The p53 tumor suppressor plays a critical role in the death of
leukemic stem and progenitor cells. As cited in previous essays, p53
protein concentrations can be increased by flax lignans.
Three natural medicines, and possibly more, can kill leukemic stem and
progenitor cells and induce the re-differentiation of leukemic cells
into their normal counterpart. NO synthetic drug or drugs can
accomplish these clinical objectives."
I wanted to pass this on so those of you interested in leukemia could
research it further. Onward and upward!
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