Lactate is a normal metabolic product. Any time you do hard work with
your muscles you are producing lactate. There is even lactate in
food, especially fermented dairy products, like yogurt.
All cells produce some lactate as a result of breaking down pyruvate.
There is a normal background level of lactate in the blood which is
recycled by the liver to make glucose, so it may be recycled. When
you run hard or lift weights the blood lactate level goes up
dramatically. This is all normal. Cancer cells are running the
anaerobic aspect of glucose utilization in much the same way a hard
working muscle cell does. A lot of extra lactate is produced. The
liver converts it back to glucose and the cancer cells grab much of
it for themselves. They use a lot more glucose than other cells.
This can create a viscious cycle in which cancer cells have hijacked
your own liver function to keep themselves fed. Other cells begin to
suffer a lack of glucose. This is, essentially, how cachexia starts.
Mike
Monday, July 7, 2008, 5:08:30 AM, you wrote:
tgc> Hello Mike,
tgc> I hope you can clarify for me...
tgc> Just a couple of days ago, while researching diabetes to see if I could help my mom, I for the first time ever read something about the liver producing glucose. I don't understand that at all -
tgc> why would the liver produce glucose and what does it produce it from (you say from lactate from the cancer cells, but what if we don't have cancer?) ?
tgc> And how is this cachexia? I learned that cachexia means wasting away and is caused when the cancer tumors use up all the nourishment for their own growth and deprive all other cells of it.
tgc> Thanks,
tgc> Angel
--
Best regards,
goldenmike mailto:goldenmike@sbcglobal.net
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