I discussed methylglyoxal with the owner of the company two years
ago. I tried to discourage him from selling this without thinking it
through. I have not seen homeopathic versions work and I thought
that the higher strength versions would present problems. The most
likely problem would be that someone's health would plummet (e.g.,
blindness), methylglyoxal would appear to the culprit, the FDA would
ban it, and all research would come to a screeching halt.
Keep in mind that methylglyoxal is a natural toxin produced by the
body. We have a whole system of glyoxalase enzymes that protects our
bodies from the advanced glycation end products associated with the
sugar metabolites such as methylglyoxal. The incautious use of
methylglyoxal would certainly increase the risk of rapid aging.
I would be very concerned about combinations with other
meds. Methlyglyoxal will undermine certain other strategies such
that neither would work (e.g. those that encourage cellular
respiration) and it will be additive with other strategies such that
its toxicity is greatly intensified (e.g., ATP decoupling agents).
Methylglyoxal is one of literally thousands of distortive
therapies. I have never seen benefit from the willy-nilly use of
such agents. They do occasionally have great value if carefully
selected from among these thousands of possibilities. Use the right
tool for the right job. You might call the internet company that
markets methylglyoxal and ask them how many of the customers who
bought it a year ago are still buying it or are even still alive. My
guess is that the company will tell you that all their customers are
alive, cured, and merrily dancing in the streets. I am very happy
for all of them.
Vincent
At 12:08 PM 3/19/2008, you wrote:
>Hi Vincent
>
>This is altogether less effusive than the first reports. Also I note
>that 2 methylglyoxal products are offered at
>www.gethealthyagain.com. Any comments on these?
>
>Jonathan
>
>
>VGammill <<mailto:vgammill%40adelphia.net>vgammill@adelphia.net> wrote:
>Jonathan,
>
>Always keep in mind that there is a prescreening process going
>on. You don't want to accept those patients for methylglyoxal who
>don't seem to be good candidates, and that is most of them. There
>are many reasons including: acute pathologies even if incipient
>(e.g., DVT, pneumonia), volume of distribution issues in
>decompensation of any essential organ system or with
>ascites/effusion, chemical and strategic incompatibilities, cancers
>in which it has been shown to ineffective or less effective (many
>lymphomas, squamous, sarcomas, leukemias, etc.), use in patients
>which with preexisting pathologies in organs that would be placed in
>greater risk with methylglyoxal use (e.g., heart, kidneys, liver,
>pancreas, eyesight).
>
>Both Manju Ray and I have had success with patients who are good
>candidates, but the patients must continue taking it. If
>discontinued, the cancer can be expected to return as evidenced by
>all tests with animal models and informal tests with humans. When
>Manju last stayed out our retreat center in Del Mar, California she
>said that she had one patient who stopped taking the methylglyoxal
>for a year and it had not yet returned. I have used more
>methylglyoxal than anyone in the western hemisphere and I have seen
>stabilization of disease in many patients who are good candidates. I
>have not seen any complete remissions in any patients who used it as
>a standalone.
>
>Methylglyoxal is less useful if there is drug resistance. It
>can be quite useful post radiation if chemotherapy was not used. If
>used wisely methylglyoxal can be quite helpful. I think knowledge of
>its best use is still in its infancy. We will know much more in 5-10 years.
>
>Vincent
>
>
[Non-text portions of this message have been removed]
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