Thank you for this - I have been able to amend my otherwise favourable account of methylglyoxal in the book I am just now preparing for press.
Jonathan
VGammill <vgammill@adelphia.net> wrote:
Jonathan,
I discussed methylglyoxal with the owner of the company two years
ago. I tried to discourage him from selling this without thinking it
through. I have not seen homeopathic versions work and I thought
that the higher strength versions would present problems. The most
likely problem would be that someone's health would plummet (e.g.,
blindness), methylglyoxal would appear to the culprit, the FDA would
ban it, and all research would come to a screeching halt.
Keep in mind that methylglyoxal is a natural toxin produced by the
body. We have a whole system of glyoxalase enzymes that protects our
bodies from the advanced glycation end products associated with the
sugar metabolites such as methylglyoxal. The incautious use of
methylglyoxal would certainly increase the risk of rapid aging.
I would be very concerned about combinations with other
meds. Methlyglyoxal will undermine certain other strategies such
that neither would work (e.g. those that encourage cellular
respiration) and it will be additive with other strategies such that
its toxicity is greatly intensified (e.g., ATP decoupling agents).
Methylglyoxal is one of literally thousands of distortive
therapies. I have never seen benefit from the willy-nilly use of
such agents. They do occasionally have great value if carefully
selected from among these thousands of possibilities. Use the right
tool for the right job. You might call the internet company that
markets methylglyoxal and ask them how many of the customers who
bought it a year ago are still buying it or are even still alive. My
guess is that the company will tell you that all their customers are
alive, cured, and merrily dancing in the streets. I am very happy
for all of them.
Vincent
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