"Breast cancer gene breakthrough 'could halt disease from spreading'
Breast cancer patients could soon benefit from a treatment that
appears to halt the disease in its tracks.
Scientists have pinpointed a key gene, which is central to the
spread of cancerous cells to other parts of the body. This is the
most common cause of death from the disease.
Experiments show the gene, known as SATB1, controls the behaviour of
more than 1,000 other genes in tumour cells.
When the gene is over-activated, the other genes run amok, easing
cancer's invasion of other parts of the body.
The US researchers found knocking out this 'kingpin' gene causes the
cancer cells to stop their runaway proliferation.
Drugs which interfere with the gene could provide valuable new
treatments for the disease which affects more than 44,000 women a
year in the UK alone.
Writing in the journal Nature, the University of California
researchers describe experiments in which human breast cancer cells
formed tumours in the lungs of mice after being injected into their
tails.
When the gene was stopped from working, the mice developed fewer or
even no tumours.
Other experiments showed that cancer cells which would not normally
spread, gain the ability to do so when SATB1 is activated.
Examination of thousands of human breast cancer tissue samples
showed that the gene is most active in patients whose prognosis is
poor."
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